Anti-inflammatory and anti-remodelling effects of ISU201, a modified form of the extracellular domain of human BST2, in experimental models of asthma: association with inhibition of histone acetylation.

Anti-inflammatory and anti-remodelling effects of ISU201, a modified form of the extracellular domain of human BST2, in experimental models of asthma: association with inhibition of histone acetylation.

There are few alternatives to glucocorticosteroids for treatment of asthma. We assessed the activity of a novel protein drug designated ISU201, the extracellular domain of the human cell surface protein BST2, stabilised by fusion with the Fc region of IgG, in mouse models of mild chronic asthma and...

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Bibliographic Details
Main Authors: Cristan Herbert, Alexander M Shadie, Melissa M Bunting, Nicodemus Tedla, Linda Garthwaite, Araluen Freeman, Hyouna Yoo, Sang-Ho Park, Rakesh K Kumar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24594933/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24594933/?tool=EBI

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