Actin dynamics provides membrane tension to merge fusing vesicles into the plasma membrane

Actin dynamics provides membrane tension to merge fusing vesicles into the plasma membrane

As vesicles fuse to the plasma membrane, they form intermediate Ω-shaped structures followed by either closure of the pore or full merging with the plasma membrane. Here Wen et al. show that dynamic actin assembly provides membrane tension to promote Ω merging in neuroendocrine cells and synapses.

Bibliographic Details
Main Authors: Peter J. Wen, Staffan Grenklo, Gianvito Arpino, Xinyu Tan, Hsien-Shun Liao, Johanna Heureaux, Shi-Yong Peng, Hsueh-Cheng Chiang, Edaeni Hamid, Wei-Dong Zhao, Wonchul Shin, Tuomas Näreoja, Emma Evergren, Yinghui Jin, Roger Karlsson, Steven N. Ebert, Albert Jin, Allen P. Liu, Oleg Shupliakov, Ling-Gang Wu
Format: Article
Language:English
Published: Nature Publishing Group 2016-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12604

Internet

https://doi.org/10.1038/ncomms12604

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