Statistical design of Phase II/III clinical trials for testing therapeutic interventions in COVID-19 patients

Statistical design of Phase II/III clinical trials for testing therapeutic interventions in COVID-19 patients

Abstract Background Because of unknown features of the COVID-19 and the complexity of the population affected, standard clinical trial designs on treatments may not be optimal in such patients. We propose two independent clinical trials designs based on careful grouping of patient and outcome measur...

Full description

Bibliographic Details
Main Authors: Shesh N. Rai, Chen Qian, Jianmin Pan, Anand Seth, Deo Kumar Srivastava, Aruni Bhatnagar
Format: Article
Language:English
Published: BMC 2020-08-01
Series:BMC Medical Research Methodology
Subjects:
Composite outcomes
COVID-19
Efficacy
Hospitalization
Interim analysis
Intubation
Online Access:http://link.springer.com/article/10.1186/s12874-020-01101-z

Internet

http://link.springer.com/article/10.1186/s12874-020-01101-z

Similar Items