Elevated Level of CD4+ T Cell Immune Activation in Acutely HIV-1-Infected Stage Associates With Increased IL-2 Production and Cycling Expression, and Subsequent CD4+ T Cell Preservation

Elevated Level of CD4+ T Cell Immune Activation in Acutely HIV-1-Infected Stage Associates With Increased IL-2 Production and Cycling Expression, and Subsequent CD4+ T Cell Preservation

Persistent immune activation is a striking consequence of HIV-1 infection and a driving force of CD4+ T cell depletion and AIDS events during chronic infection. High level of T cell immune activation associates with antiretroviral therapy (ART)-treated clinical outcomes in chronically HIV-1-infected...

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Bibliographic Details
Main Authors: Huan Xia, Wei Jiang, Xin Zhang, Ling Qin, Bin Su, Zhen Li, Jianping Sun, Yonghong Zhang, Tong Zhang, Xiaofan Lu, Hao Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
acute HIV-1 infection
T cell immune activation
CD4+ T cell
immune exhaustion molecules
T cell preservation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00616/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00616/full

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