Plant-derived SAC domain of PAR-4 (Prostate Apoptosis Response 4) exhibits growth inhibitory effects in prostate cancer cells

Plant-derived SAC domain of PAR-4 (Prostate Apoptosis Response 4) exhibits growth inhibitory effects in prostate cancer cells

The gene Par-4 (Prostate Apoptosis Response 4) was originally identified in prostate cancer cells undergoing apoptosis and its product Par-4 showed cancer specific pro-apoptotic activity. Particularly, the SAC domain of Par-4 (SAC-Par-4) selectively kills cancer cells leaving normal cells unaffected...

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Bibliographic Details
Main Authors: Shayan eSarkar, Sumeet eJain, Vineeta eRai, Dipak Kumar Sahoo, Sumita eRaha, Sujit eSuklabaidya, Shantibhushan eSenapati, Vivek M Rangnekar, Indu Bhushan Maiti, Nrisingha eDey
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Plant Science
Subjects:
Apoptosis
Glycosylation
Molecular Farming
transgenic plants
fusion protein
SAC domain of Par-4
Online Access:http://journal.frontiersin.org/Journal/10.3389/fpls.2015.00822/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fpls.2015.00822/full

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