Atherosclerotic Plaque Stability Is Affected by the Chemokine CXCL10 in Both Mice and Humans

Background. The chemokine CXCL10 is specifically upregulated during experimental development of plaque with an unstable phenotype. In this study we evaluated the functional consequences of these findings in mice and humans. Methods and Results. In ApoE-/- mice, we induced unstable plaque with using...

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Bibliographic Details
Main Authors: Dolf Segers, Jonathan A. Lipton, Pieter J. M. Leenen, Caroline Cheng, Dennie Tempel, Gerard Pasterkamp, Frans L. Moll, Rini de Crom, Rob Krams
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:International Journal of Inflammation
Online Access:http://dx.doi.org/10.4061/2011/936109