Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells

Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells

Abstract The transcription factor ∆Np63 is a master regulator of epithelial cell identity and essential for the survival of squamous cell carcinoma (SCC) of lung, head and neck, oesophagus, cervix and skin. Here, we report that the deubiquitylase USP28 stabilizes ∆Np63 and maintains elevated ∆NP63 l...

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Bibliographic Details
Main Authors: Cristian Prieto‐Garcia, Oliver Hartmann, Michaela Reissland, Fabian Braun, Thomas Fischer, Susanne Walz, Christina Schülein‐Völk, Ursula Eilers, Carsten P Ade, Marco A Calzado, Amir Orian, Hans M Maric, Christian Münch, Mathias Rosenfeldt, Martin Eilers, Markus E Diefenbacher
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:EMBO Molecular Medicine
Subjects:
∆Np63
MYC
NOTCH
squamous cell carcinoma
USP28
Online Access:https://doi.org/10.15252/emmm.201911101

Internet

https://doi.org/10.15252/emmm.201911101

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