PDGF Promotes the Warburg Effect in Pulmonary Arterial Smooth Muscle Cells via Activation of the PI3K/AKT/mTOR/HIF-1α Signaling Pathway

PDGF Promotes the Warburg Effect in Pulmonary Arterial Smooth Muscle Cells via Activation of the PI3K/AKT/mTOR/HIF-1α Signaling Pathway

Background/Aims: The enhanced proliferation of pulmonary arterial smooth muscle cells (PASMCs) is a central pathological component in pulmonary arterial hypertension (PAH). Both the Warburg effect and platelet-derived growth factor (PDGF) are involved in the proliferation of PASMCs. However, the me...

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Bibliographic Details
Main Authors: Yunbin Xiao, Hongyan Peng, Chenliang Hong, Zhi Chen, Xicheng Deng, Aiping Wang, Fang Yang, Li Yang, Chen Chen, Xuping Qin
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Warburg effect
Pulmonary arterial smooth muscle cells
Platelet-derived growth factor
Online Access:http://www.karger.com/Article/FullText/479401

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http://www.karger.com/Article/FullText/479401

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