Haploinsufficiency of NR3C1 drives glucocorticoid resistance in adult acute lymphoblastic leukemia cells by down-regulating the mitochondrial apoptosis axis, and is sensitive to Bcl-2 blockage

Haploinsufficiency of NR3C1 drives glucocorticoid resistance in adult acute lymphoblastic leukemia cells by down-regulating the mitochondrial apoptosis axis, and is sensitive to Bcl-2 blockage

Abstract Background Relapse represents the leading cause of death in both child and adult patients with acute lymphoblastic leukemia (ALL). Development of chemo-resistance is ultimately responsible for treatment failure and relapse, therefore understanding the molecular basis underlying resistance i...

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Bibliographic Details
Main Authors: Haowen Xiao, Yingying Ding, Yang Gao, Li-Mengmeng Wang, Huafang Wang, Lijuan Ding, Xiaoqing Li, Xiaohong Yu, He Huang
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Cancer Cell International
Subjects:
Haploinsufficiency
NR3C1
Glucocorticoid resistance
Acute lymphoblastic leukemia
Mitochondrial apoptosis axis
Bcl-2 blockage
Online Access:http://link.springer.com/article/10.1186/s12935-019-0940-9

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http://link.springer.com/article/10.1186/s12935-019-0940-9

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