Topological structure of the space of phenotypes: the case of RNA neutral networks.

The evolution and adaptation of molecular populations is constrained by the diversity accessible through mutational processes. RNA is a paradigmatic example of biopolymer where genotype (sequence) and phenotype (approximated by the secondary structure fold) are identified in a single molecule. The e...

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Bibliographic Details
Main Authors: Jacobo Aguirre, Javier M Buldú, Michael Stich, Susanna C Manrubia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22028856/?tool=EBI