High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase.

High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase.

Leishmania species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs). Cdc2-related kinase 3 (CRK3), an essential CDK in Leishmania and functional orthologue of human CDK1, can form an active protein kinase complex with Leishmania cyclins C...

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Bibliographic Details
Main Authors: Roderick G Walker, Graeme Thomson, Kirk Malone, Matthew W Nowicki, Elaine Brown, David G Blake, Nicholas J Turner, Malcolm D Walkinshaw, Karen M Grant, Jeremy C Mottram
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3071374?pdf=render

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http://europepmc.org/articles/PMC3071374?pdf=render

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