Blockade of IL-33R/ST2 Signaling Attenuates Toxoplasma gondii Ileitis Depending on IL-22 Expression

Blockade of IL-33R/ST2 Signaling Attenuates Toxoplasma gondii Ileitis Depending on IL-22 Expression

Oral T. gondii infection (30 cysts of 76K strain) induces acute lethal ileitis in sensitive C57BL/6 (B6) mice with increased expression of IL-33 and its receptor ST2 in the ileum. Here we show that IL-33 is involved in ileitis, since absence of IL-33R/ST2 attenuated neutrophilic inflammation and Th1...

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Bibliographic Details
Main Authors: Bernhard Ryffel, Feng Huang, Pauline Robinet, Corine Panek, Isabelle Couillin, François Erard, Julie Piotet, Marc Le Bert, Claire Mackowiak, Marbel Torres Arias, Isabelle Dimier-Poisson, Song Guo Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
Toxoplasma gondii
IL-33/ST2 receptor
neutralizing antibody
IL-22
parasite-induced ileitis
innate immunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00702/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00702/full

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