Long non-coding RNA HOTAIR induces GLI2 expression through Notch signalling in systemic sclerosis dermal fibroblasts

Long non-coding RNA HOTAIR induces GLI2 expression through Notch signalling in systemic sclerosis dermal fibroblasts

Abstract Objectives Systemic sclerosis (SSc) is characterised by tissue fibrosis of the major organs of the body including the skin, lungs and heart. We have previously reported that the lncRNA HOTAIR plays a central role in the activation of SSc myofibroblasts, the key cellular elements of fibrosis...

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Bibliographic Details
Main Authors: Christopher W. Wasson, Rebecca L. Ross, Rebecca Wells, Clarissa Corinaldesi, Ioanna Ch. Georgiou, Natalia A. Riobo-Del Galdo, Francesco Del Galdo
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Arthritis Research & Therapy
Subjects:
Systemic sclerosis
Hedgehog signalling
Epigenetics
Long non-coding RNA
HOTAIR
Online Access:https://doi.org/10.1186/s13075-020-02376-9

Internet

https://doi.org/10.1186/s13075-020-02376-9

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