Identifying prognostic features by bottom-up approach and correlating to drug repositioning.

Traditionally top-down method was used to identify prognostic features in cancer research. That is to say, differentially expressed genes usually in cancer versus normal were identified to see if they possess survival prediction power. The problem is that prognostic features identified from one set...

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Bibliographic Details
Main Authors: Wei Li, Jian Yu, Baofeng Lian, Han Sun, Jing Li, Menghuan Zhang, Ling Li, Yixue Li, Qian Liu, Lu Xie
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4349868?pdf=render