Oxidative Stress and Neurodegeneration: Interconnected Processes in PolyQ Diseases

Oxidative Stress and Neurodegeneration: Interconnected Processes in PolyQ Diseases

Neurodegenerative polyglutamine (polyQ) disorders are caused by trinucleotide repeat expansions within the coding region of disease-causing genes. PolyQ-expanded proteins undergo conformational changes leading to the formation of protein inclusions which are associated with selective neuronal degene...

Full description

Bibliographic Details
Main Authors: Ioannis Gkekas, Anna Gioran, Marina Kleopatra Boziki, Nikolaos Grigoriadis, Niki Chondrogianni, Spyros Petrakis
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Antioxidants
Subjects:
polyglutamine
oxidative stress
proteasome impairment
microglia activation
neurodegeneration
neuroinflammation
Online Access:https://www.mdpi.com/2076-3921/10/9/1450

Internet

https://www.mdpi.com/2076-3921/10/9/1450

Similar Items