Comparison of analytical techniques to quantitate the capsid content of adeno-associated viral vectors

Comparison of analytical techniques to quantitate the capsid content of adeno-associated viral vectors

Adeno-associated virus (AAV) vectors, which contain a DNA transgene packaged into a protein capsid, have shown tremendous therapeutic potential in recent years. An inherent characteristic of the manufacturing process is production of empty capsids that lack the transgene and are therefore unable to...

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Bibliographic Details
Main Authors: Amanda K. Werle, Thomas W. Powers, James F. Zobel, Caitlin N. Wappelhorst, Martin F. Jarrold, Nicholas A. Lyktey, Courtney D.K. Sloan, Andrew J. Wolf, Sharee Adams-Hall, Phoebe Baldus, Herbert A. Runnels
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
adeno-associated virus (AAV)
capsid content
empty capsid
intermediate capsid
full capsid
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121001352

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http://www.sciencedirect.com/science/article/pii/S2329050121001352

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