Epigenetic induction of EGR-1 expression by the amyloid precursor protein during exposure to novelty.

Epigenetic induction of EGR-1 expression by the amyloid precursor protein during exposure to novelty.

Following transcriptome comparison of primary cultures isolated from brain of mice expressing or not the amyloid precursor protein APP, we found transcription of the EGR-1 gene to be regulated by APP. In primary cultures of cortical neurons, APP significantly down regulated EGR-1 expression at both...

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Bibliographic Details
Main Authors: Aurélie Hendrickx, Nathalie Pierrot, Bernadette Tasiaux, Olivier Schakman, Jean-Pierre Brion, Pascal Kienlen-Campard, Charles De Smet, Jean-Noël Octave
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3774615?pdf=render

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http://europepmc.org/articles/PMC3774615?pdf=render

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