Potential Pharmacokinetic Drug–Drug Interaction Between Harmine, a Cholinesterase Inhibitor, and Memantine, a Non-Competitive <i>N</i>-Methyl-<span style="font-variant: small-caps">d</span>-Aspartate Receptor Antagonist

Potential Pharmacokinetic Drug–Drug Interaction Between Harmine, a Cholinesterase Inhibitor, and Memantine, a Non-Competitive <i>N</i>-Methyl-<span style="font-variant: small-caps">d</span>-Aspartate Receptor Antagonist

Harmine (HAR) is a beta-carboline alkaloid widely distributed in nature. It exhibits psychopharmacological effects of improving learning and memory. However, excessive dose of HAR can cause central tremor toxicity, which may be related to the glutamate system. Memantine (MEM) is a non-competitive &l...

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Bibliographic Details
Main Authors: Yunpeng Zhang, Shuping Li, Youxu Wang, Gang Deng, Ning Cao, Chao Wu, Wenzheng Ding, Yuwen Wang, Xuemei Cheng, Changhong Wang
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Molecules
Subjects:
harmine
memantine
drug-drug interaction
pharmacokinetics
Alzheimer’s disease
liquid chromatography-mass spectrometry
Online Access:https://www.mdpi.com/1420-3049/24/7/1430

Internet

https://www.mdpi.com/1420-3049/24/7/1430

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