Assessment of tropism and effectiveness of new primate-derived hybrid recombinant AAV serotypes in the mouse and primate retina.

Assessment of tropism and effectiveness of new primate-derived hybrid recombinant AAV serotypes in the mouse and primate retina.

Adeno-associated viral vectors (AAV) have been shown to be safe in the treatment of retinal degenerations in clinical trials. Thus, improving the efficiency of viral gene delivery has become increasingly important to increase the success of clinical trials. In this study, structural domains of diffe...

Full description

Bibliographic Details
Main Authors: Peter Charbel Issa, Samantha R De Silva, Daniel M Lipinski, Mandeep S Singh, Alexandre Mouravlev, Qisheng You, Alun R Barnard, Mark W Hankins, Matthew J During, Robert E Maclaren
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3621895?pdf=render

Internet

http://europepmc.org/articles/PMC3621895?pdf=render

Similar Items