Estrogen-Related Receptor γ Agonist DY131 Ameliorates Lipopolysaccharide-Induced Acute Liver Injury

Estrogen-Related Receptor γ Agonist DY131 Ameliorates Lipopolysaccharide-Induced Acute Liver Injury

Sepsis-associated liver dysfunction remains a challenge in clinical practice with high mortality and limited specific therapies. DY131 is a pharmacological agonist of the orphan receptor estrogen-related receptor (ERR) γ which plays a crucial role in regulating energy generation, oxidative metabolis...

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Bibliographic Details
Main Authors: Haoyang Ma, Jiaye Liu, Yang Du, Shengnan Zhang, Weidong Cao, Zhanjun Jia, Wei Gong, Aihua Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
ERRγ
DY131
lipopolysaccharide
acute liver injury
sepsis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.626166/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.626166/full

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