Systematic Prediction of Scaffold Proteins Reveals New Design Principles in Scaffold-Mediated Signal Transduction.

Scaffold proteins play a crucial role in facilitating signal transduction in eukaryotes by bringing together multiple signaling components. In this study, we performed a systematic analysis of scaffold proteins in signal transduction by integrating protein-protein interaction and kinase-substrate re...

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Bibliographic Details
Main Authors: Jianfei Hu, Johnathan Neiswinger, Jin Zhang, Heng Zhu, Jiang Qian
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4578958?pdf=render