Targeting the RHOA pathway improves learning and memory in adult Kctd13 and 16p11.2 deletion mouse models

Targeting the RHOA pathway improves learning and memory in adult Kctd13 and 16p11.2 deletion mouse models

Abstract Background Gene copy number variants play an important role in the occurrence of neurodevelopmental disorders. Particularly, the deletion of the 16p11.2 locus is associated with autism spectrum disorder, intellectual disability, and several other features. Earlier studies highlighted the im...

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Bibliographic Details
Main Authors: Sandra Martin Lorenzo, Valérie Nalesso, Claire Chevalier, Marie-Christine Birling, Yann Herault
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Molecular Autism
Subjects:
Copy number variation
Neurodevelopment
Intellectual disability
Autism spectrum disorders
KCTD13
Mouse model
Online Access:https://doi.org/10.1186/s13229-020-00405-7

Internet

https://doi.org/10.1186/s13229-020-00405-7

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