Assessment of mGluR5 KO mice under conditions of low stress using a rodent touchscreen apparatus reveals impaired behavioural flexibility driven by perseverative responses

Assessment of mGluR5 KO mice under conditions of low stress using a rodent touchscreen apparatus reveals impaired behavioural flexibility driven by perseverative responses

Abstract Genetic and pharmacological manipulations targeting metabotropic glutamate receptor 5 (mGluR5) affect performance in behavioural paradigms that depend on cognitive flexibility. Many of these studies involved exposing mice to highly stressful conditions including electric foot shocks or wate...

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Bibliographic Details
Main Authors: Jisoo Lim, Eosu Kim, Hyun Jong Noh, Shinwon Kang, Benjamin U. Phillips, Dong Goo Kim, Timothy J. Bussey, Lisa Saksida, Christopher J. Heath, Chul Hoon Kim
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Molecular Brain
Subjects:
mGluR5
Behavioural flexibility
Perseveration
Reversal learning
Extinction
Progressive ratio schedule
Online Access:http://link.springer.com/article/10.1186/s13041-019-0441-8

Internet

http://link.springer.com/article/10.1186/s13041-019-0441-8

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