The integration of signalling and the spatial organization of the T cell synapse

The integration of signalling and the spatial organization of the T cell synapse

Engagement of the T cell antigen receptor (TCR) triggers signalling pathways that lead to T cell selection, differentiation and clonal expansion. Superimposed onto the biochemical network is a spatial organization that describes individual receptor molecules, dimers, oligomers and higher order struc...

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Bibliographic Details
Main Authors: Jeremie eRossy, David J Williamson, Carola eBenzing, Katharina eGaus
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-11-01
Series:Frontiers in Immunology
Subjects:
T cell receptor
T cell activation
membrane organisation
receptor oligomerization
signalling assembly
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00352/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00352/full

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