Rational drug design, synthesis, and biological evaluation of novel chiral tetrahydronaphthalene-fused spirooxindole as MDM2-CDK4 dual inhibitor against glioblastoma

Rational drug design, synthesis, and biological evaluation of novel chiral tetrahydronaphthalene-fused spirooxindole as MDM2-CDK4 dual inhibitor against glioblastoma

Simultaneous inhibition of MDM2 and CDK4 may be an effective treatment against glioblastoma. A collection of chiral spirocyclic tetrahydronaphthalene (THN)-oxindole hybrids for this purpose have been developed. Appropriate stereochemistry in THN-fused spirooxindole compounds is key to their inhibito...

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Bibliographic Details
Main Authors:	Biao Wang, Fu Peng, Wei Huang, Jin Zhou, Nan Zhang, Jia Sheng, Phensinee Haruehanroengra, Gu He, Bo Han
Format:	Article
Language:	English
Published:	Elsevier 2020-08-01
Series:	Acta Pharmaceutica Sinica B
Subjects:	Chiral tetrahydronaphthalene-fused spirooxindoles Synthesis MDM2-CDK4 dual inhibitors Glioblastoma Structure–activity relationship Apoptosis
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211383519308706

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