Rational drug design, synthesis, and biological evaluation of novel chiral tetrahydronaphthalene-fused spirooxindole as MDM2-CDK4 dual inhibitor against glioblastoma

Rational drug design, synthesis, and biological evaluation of novel chiral tetrahydronaphthalene-fused spirooxindole as MDM2-CDK4 dual inhibitor against glioblastoma

Simultaneous inhibition of MDM2 and CDK4 may be an effective treatment against glioblastoma. A collection of chiral spirocyclic tetrahydronaphthalene (THN)-oxindole hybrids for this purpose have been developed. Appropriate stereochemistry in THN-fused spirooxindole compounds is key to their inhibito...

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Bibliographic Details
Main Authors: Biao Wang, Fu Peng, Wei Huang, Jin Zhou, Nan Zhang, Jia Sheng, Phensinee Haruehanroengra, Gu He, Bo Han
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Chiral tetrahydronaphthalene-fused spirooxindoles
Synthesis
MDM2-CDK4 dual inhibitors
Glioblastoma
Structure–activity relationship
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383519308706

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http://www.sciencedirect.com/science/article/pii/S2211383519308706

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