Adult-like anti-mycobacterial T cell and in vivo dendritic cell responses following neonatal immunization with Ag85B-ESAT-6 in the IC31 adjuvant.

BACKGROUND: With the exception of some live vaccines, e.g. BCG, subunit vaccines formulated with "classical" adjuvants do not induce similar responses in neonates as in adults. The usual neonatal profile is characterized by lower levels of TH1-associated biomarkers. This has hampered the d...

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Bibliographic Details
Main Authors: Arun T Kamath, Anne-Françoise Rochat, Mario P Valenti, Else Marie Agger, Karen Lingnau, Peter Andersen, Paul-Henri Lambert, Claire-Anne Siegrist
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2577009?pdf=render