Exploiting ecology in drug pulse sequences in favour of population reduction.

A deterministic population dynamics model involving birth and death for a two-species system, comprising a wild-type and more resistant species competing via logistic growth, is subjected to two distinct stress environments designed to mimic those that would typically be induced by temporal variatio...

Full description

Bibliographic Details
Main Authors: Marianne Bauer, Isabella R Graf, Vudtiwat Ngampruetikorn, Greg J Stephens, Erwin Frey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-09-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC5643144?pdf=render