The Immunogenicity in Mice of HCV Core Delivered as DNA Is Modulated by Its Capacity to Induce Oxidative Stress and Oxidative Stress Response

The Immunogenicity in Mice of HCV Core Delivered as DNA Is Modulated by Its Capacity to Induce Oxidative Stress and Oxidative Stress Response

HCV core is an attractive HCV vaccine target, however, clinical or preclinical trials of core-based vaccines showed little success. We aimed to delineate what restricts its immunogenicity and improve immunogenic performance in mice. We designed plasmids encoding full-length HCV 1b core and its varia...

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Bibliographic Details
Main Authors: Juris Jansons, Irina Sominskaya, Natalia Petrakova, Elizaveta S. Starodubova, Olga A. Smirnova, Ekaterina Alekseeva, Ruta Bruvere, Olesja Eliseeva, Dace Skrastina, Elena Kashuba, Marija Mihailova, Sergey N. Kochetkov, Alexander V. Ivanov, Maria G. Isaguliants
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Cells
Subjects:
n/a
Online Access:http://www.mdpi.com/2073-4409/8/3/208

Internet

http://www.mdpi.com/2073-4409/8/3/208

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