Rosiglitazone Inhibits Angiotensin II-Induced Proliferation of Glomerular Mesangial Cells via the Gαq/Plcβ4/TRPC Signaling Pathway

Rosiglitazone Inhibits Angiotensin II-Induced Proliferation of Glomerular Mesangial Cells via the Gαq/Plcβ4/TRPC Signaling Pathway

Background/Aims: Mesangial cell proliferation and extracellular matrix accumulation (ECM) deposition play an important role in the pathogenesis of glomerulosclerosis. TRPC and PPAR-γ can regulate cell proliferation. Angiotensin II (AngII) can induce mesangial cell proliferation and affect TRPC expre...

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Bibliographic Details
Main Authors: Linting Wei, Jiarong Mao, Jiamei Lu, Jie Gao, Dan Zhu, Lifang Tian, Zhao Chen, Lining Jia, Li Wang, Rongguo Fu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-12-01
Series:Cellular Physiology and Biochemistry
Subjects:
RSG
TRPC
HBZY-1
Proliferation
PPAR-γ
RGS4
Online Access:https://www.karger.com/Article/FullText/486056

Internet

https://www.karger.com/Article/FullText/486056

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