Impact of <i>BRCA</i> Mutation Status on Tumor Infiltrating Lymphocytes (TILs), Response to Treatment, and Prognosis in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy

Impact of <i>BRCA</i> Mutation Status on Tumor Infiltrating Lymphocytes (TILs), Response to Treatment, and Prognosis in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy

Introduction: Five to 10% of breast cancers (BCs) occur in a genetic predisposition context (mainly <i>BRCA</i> pathogenic variant). Nevertheless, little is known about immune tumor infiltration, response to neoadjuvant chemotherapy (NAC), pathologic complete response (pCR) and adverse e...

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Bibliographic Details
Main Authors: Beatriz Grandal, Clémence Evrevin, Enora Laas, Isabelle Jardin, Sonia Rozette, Lucie Laot, Elise Dumas, Florence Coussy, Jean-Yves Pierga, Etienne Brain, Claire Saule, Dominique Stoppa-Lyonnet, Sophie Frank, Claire Sénéchal, Marick Lae, Diane De Croze, Guillaume Bataillon, Julien Guerin, Fabien Reyal, Anne-Sophie Hamy
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cancers
Subjects:
BRCA
TILs
pCR
NAC
immunotherapy
Online Access:https://www.mdpi.com/2072-6694/12/12/3681

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https://www.mdpi.com/2072-6694/12/12/3681

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