Blood circulation of soft nanomaterials is governed by dynamic remodeling of protein opsonins at nano-biointerface

The blood circulation time is important to the biomedical application of nanomaterials. Here, the authors explore the effect of protein corona formation on the blood residency of nanomaterials and show circulation times are governed by the dynamic remodelling of protein opsonins in vivo.

Bibliographic Details
Main Authors: Srinivas Abbina, Lily E. Takeuchi, Parambath Anilkumar, Kai Yu, Jason C. Rogalski, Rajesh A. Shenoi, Iren Constantinescu, Jayachandran N. Kizhakkedathu
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16772-x