Weak Organic Acids Decrease Borrelia burgdorferi Cytoplasmic pH, Eliciting an Acid Stress Response and Impacting RpoN- and RpoS-Dependent Gene Expression

Weak Organic Acids Decrease Borrelia burgdorferi Cytoplasmic pH, Eliciting an Acid Stress Response and Impacting RpoN- and RpoS-Dependent Gene Expression

The spirochete Borrelia burgdorferi survives in its tick vector, Ixodes scapularis, or within various hosts. To transition between and survive in these distinct niches, B. burgdorferi changes its gene expression in response to environmental cues, both biochemical and physiological. Exposure of B. bu...

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Bibliographic Details
Main Authors: Daniel P. Dulebohn, Crystal L. Richards, Hua Su, Kevin A. Lawrence, Frank C. Gherardini
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Microbiology
Subjects:
Lyme disease
gene regulation
arthropod vector
acid stress response
virulence factor expression
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.01734/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.01734/full

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