A randomised, double-blind, placebo-controlled study to evaluate the efficacy of oral azithromycin as a supplement to standard care for adult patients with acute exacerbations of asthma (the AZALEA trial)

A randomised, double-blind, placebo-controlled study to evaluate the efficacy of oral azithromycin as a supplement to standard care for adult patients with acute exacerbations of asthma (the AZALEA trial)

Background: Bacterial infections are implicated in the pathogenesis of asthma exacerbation but guidelines recommend that antibiotics should not be administered. Telithromycin shows clinical benefit compared with placebo but toxicity limits its use. Objective: To evaluate the efficacy of azithromycin...

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Bibliographic Details
Main Authors: Sebastian L Johnston, Matyas Szigeti, Mary Cross, Christopher Brightling, Rekha Chaudhuri, Timothy Harrison, Adel Mansur, Laura Robison, Zahid Sattar, David Jackson, Patrick Mallia, Ernie Wong, Christopher Corrigan, Bernard Higgins, Philip Ind, Dave Singh, Neil Thomson, Deborah Ashby, Anoop Chauhan
Format: Article
Language:English
Published: NIHR Journals Library 2016-10-01
Series:Efficacy and Mechanism Evaluation
Online Access:https://doi.org/10.3310/eme03080

Internet

https://doi.org/10.3310/eme03080

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