Quantitative correlation between promoter methylation and messenger RNA levels of the reduced folate carrier

Quantitative correlation between promoter methylation and messenger RNA levels of the reduced folate carrier

<p>Abstract</p> <p>Background</p> <p>Methotrexate (MTX) uptake is mediated by the reduced folate carrier (RFC). Defective drug uptake in association with decreased RFC expression is a common mechanism of MTX resistance in many tumor types. Heavy promoter methylation was...

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Bibliographic Details
Main Authors: Kheradpour Albert, Banerjee Debabrata, Kim Hansoo, Hoang Bang H, Li Wei-Wei, Yang Rui, Healey John H, Meyers Paul A, Bertino Joseph R, Gorlick Richard
Format: Article
Language:English
Published: BMC 2008-05-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/8/124

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http://www.biomedcentral.com/1471-2407/8/124

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