Further Evidence That MicroRNAs Can Play a Role in Hemophilia A Disease Manifestation: F8 Gene Downregulation by miR-19b-3p and miR-186-5p

Further Evidence That MicroRNAs Can Play a Role in Hemophilia A Disease Manifestation: F8 Gene Downregulation by miR-19b-3p and miR-186-5p

Hemophilia A (HA) is a F8 gene mutational disorder resulting in deficiency or dysfunctional FVIII protein. However, surprisingly, in few cases, HA is manifested even without mutations in F8. To understand this anomaly, we recently sequenced microRNAs (miRNAs) of two patients with mild and moderate H...

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Bibliographic Details
Main Authors: Katarzyna I. Jankowska, Joseph McGill, Behnaz Pezeshkpoor, Johannes Oldenburg, Zuben E. Sauna, Chintamani D. Atreya
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
coagulation factor VIII
hemophilia A
microRNA
FVIII deficiency
RNA affinity purification
thrombosis
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00669/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00669/full

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