Dasatinib Attenuates Pressure Overload Induced Cardiac Fibrosis in a Murine Transverse Aortic Constriction Model.

Dasatinib Attenuates Pressure Overload Induced Cardiac Fibrosis in a Murine Transverse Aortic Constriction Model.

Reactive cardiac fibrosis resulting from chronic pressure overload (PO) compromises ventricular function and contributes to congestive heart failure. We explored whether nonreceptor tyrosine kinases (NTKs) play a key role in fibrosis by activating cardiac fibroblasts (CFb), and could potentially ser...

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Bibliographic Details
Main Authors: Sundaravadivel Balasubramanian, Dorea L Pleasant, Harinath Kasiganesan, Lakeya Quinones, Yuhua Zhang, Kamala P Sundararaj, Sandra Roche, Robert O'Connor, Amy D Bradshaw, Dhandapani Kuppuswamy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4601773?pdf=render

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http://europepmc.org/articles/PMC4601773?pdf=render

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