Knock out of S1P3 receptor signaling attenuates inflammation and fibrosis in bleomycin-induced lung injury mice model.

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in many critical cellular processes, including proliferation, migration, and angiogenesis, through interaction with a family of five G protein-coupled receptors (S1P1-5). Some reports have implicated S1P as an important in...

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Main Authors: Ken Murakami, Masataka Kohno, Masatoshi Kadoya, Hidetake Nagahara, Wataru Fujii, Takahiro Seno, Aihiro Yamamoto, Ryo Oda, Hiroyoshi Fujiwara, Toshikazu Kubo, Satoshi Morita, Hiroshi Nakada, Timothy Hla, Yutaka Kawahito
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25198418/?tool=EBI