Abnormal ADAM17 expression causes airway fibrosis in chronic obstructive asthma

Abnormal ADAM17 expression causes airway fibrosis in chronic obstructive asthma

Patients with chronic obstructive asthma (COA) develop airflow obstruction caused by subepithelial fibrosis. Although a disintegrin and metalloproteinase 17 (ADAM17) has been implicated in lung inflammation and tissue fibrosis, its role in airway fibrosis in COA has not been explored. Here, we found...

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Bibliographic Details
Main Authors: Jing-Yun Chen, Wun-Hao Cheng, Kang-Yun Lee, Han-Pin Kuo, Kian Fan Chung, Chia-Ling Chen, Bing-Chang Chen, Chien-Huang Lin
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Chronic obstructive asthma
Airway fibrosis
ADAM17
EGFR
Human lung fibroblasts
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221004832

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http://www.sciencedirect.com/science/article/pii/S0753332221004832

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