Clinical evidence that immunogenic cell death sensitizes to PD-1/PD-L1 blockade

In preclinical in vivo models of cancer, the induction of immunogenic cell death (ICD) sensitizes to subsequent immunotherapy. Several clinical trials now confirm that pretreatment with ICD-inducing anthracyclines sensitizes to immune checkpoint blockade targeting PD-1 and PD-L1 interaction. These f...

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Bibliographic Details
Main Authors: Oliver Kepp, Laurence Zitvogel, Guido Kroemer
Format: Article
Language:English
Published: Taylor & Francis Group 2019-10-01
Series:OncoImmunology
Subjects:
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1637188