Plasmodium Impairs Antibacterial Innate Immunity to Systemic Infections in Part Through Hemozoin-Bound Bioactive Molecules

Plasmodium Impairs Antibacterial Innate Immunity to Systemic Infections in Part Through Hemozoin-Bound Bioactive Molecules

One complication of malaria is increased susceptibility to invasive bacterial infections. Plasmodium infections impair host immunity to non-Typhoid Salmonella (NTS) through heme-oxygenase I (HO-I)-induced release of immature granulocytes and myeloid cell-derived IL-10. Yet, it is not known if these...

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Bibliographic Details
Main Authors: Christopher L. Harding, Nicolas F. Villarino, Elena Valente, Evelin Schwarzer, Nathan W. Schmidt
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Plasmodium
malaria
immunosuppression
co-infection
bacteria
innate immunity
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.00328/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2020.00328/full

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