Extracellular signal-regulated kinase 1/2 is required for complement component C1q and fibronectin dependent enhancement of Fcγ- receptor mediated phagocytosis in mouse and human cells

Extracellular signal-regulated kinase 1/2 is required for complement component C1q and fibronectin dependent enhancement of Fcγ- receptor mediated phagocytosis in mouse and human cells

Abstract Background C1q is a soluble pattern recognition protein that regulates multiple leukocyte functions, and deficiency in C1q results in autoimmunity. C1q stimulates enhanced phagocytic function through multiple mechanisms including the rapid enhancement of Fcγ receptor (FcγR) -mediated phagoc...

Full description

Bibliographic Details
Main Authors: Emily A. Willmann, Vesna Pandurovic, Anna Jokinen, Danielle Beckley, Suzanne S. Bohlson
Format: Article
Language:English
Published: BMC 2020-12-01
Series:BMC Immunology
Subjects:
C1q
Complement
Fibronectin
Phagocytosis
ERK1/2
Fcγ-receptor
Online Access:https://doi.org/10.1186/s12865-020-00393-6

Internet

https://doi.org/10.1186/s12865-020-00393-6

Similar Items