Notch3 inhibits cell proliferation and tumorigenesis and predicts better prognosis in breast cancer through transactivating PTEN

Notch3 inhibits cell proliferation and tumorigenesis and predicts better prognosis in breast cancer through transactivating PTEN

Abstract Notch receptors (Notch1–4) play critical roles in tumorigenesis and metastasis of malignant tumors, including breast cancer. Although abnormal Notch activation is related to various tumors, the importance of single receptors and their mechanism of activation in distinct breast cancer subtyp...

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Bibliographic Details
Main Authors: Yong-Qu Zhang, Yuan-Ke Liang, Yang Wu, Min Chen, Wei-Ling Chen, Rong-Hui Li, Yun-Zhu Zeng, Wen-He Huang, Jun-Dong Wu, De Zeng, Wen-Liang Gao, Chun-Fa Chen, Hao-Yu Lin, Rui-Qin Yang, Jiang-Wen Zhu, Wan-Ling Liu, Jing-Wen Bai, Min Wei, Xiao-Long Wei, Guo-Jun Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03735-3

Internet

https://doi.org/10.1038/s41419-021-03735-3

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