Synthesis and Antiplatelet Activity of Antithrombotic Thiourea Compounds: Biological and Structure-Activity Relationship Studies

Synthesis and Antiplatelet Activity of Antithrombotic Thiourea Compounds: Biological and Structure-Activity Relationship Studies

The incidence of hematological disorders has increased steadily in Western countries despite the advances in drug development. The high expression of the multi-resistance protein 4 in patients with transitory aspirin resistance, points to the importance of finding new molecules, including those that...

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Bibliographic Details
Main Authors: André Luiz Lourenço, Max Seidy Saito, Luís Eduardo Gomes Dorneles, Gil Mendes Viana, Plínio Cunha Sathler, Lúcia Cruz de Sequeira Aguiar, Marcelo de Pádula, Thaisa Francielle Souza Domingos, Aline Guerra Manssour Fraga, Carlos Rangel Rodrigues, Valeria Pereira de Sousa, Helena Carla Castro, Lucio Mendes Cabral
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:Molecules
Subjects:
thioureas
antiplatelet properties
in silico evaluation
Online Access:http://www.mdpi.com/1420-3049/20/4/7174

Internet

http://www.mdpi.com/1420-3049/20/4/7174

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