A Liver-Centric Multiscale Modeling Framework for Xenobiotics.

A Liver-Centric Multiscale Modeling Framework for Xenobiotics.

We describe a multi-scale, liver-centric in silico modeling framework for acetaminophen pharmacology and metabolism. We focus on a computational model to characterize whole body uptake and clearance, liver transport and phase I and phase II metabolism. We do this by incorporating sub-models that spa...

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Bibliographic Details
Main Authors: James P Sluka, Xiao Fu, Maciej Swat, Julio M Belmonte, Alin Cosmanescu, Sherry G Clendenon, John F Wambaugh, James A Glazier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5026379?pdf=render

Internet

http://europepmc.org/articles/PMC5026379?pdf=render

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