Endocytosis and Trafficking of Heparan Sulfate Proteoglycans in Triple-Negative Breast Cancer Cells Unraveled with a Polycationic Peptide

Endocytosis and Trafficking of Heparan Sulfate Proteoglycans in Triple-Negative Breast Cancer Cells Unraveled with a Polycationic Peptide

The process of heparan sulfate proteoglycan (HSPG) internalization has been described as following different pathways. The tumor-specific branched NT4 peptide has been demonstrated to bind HSPGs on the plasma membrane and to be internalized in tumor cell lines. The polycationic peptide has been also...

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Bibliographic Details
Main Authors: Elisabetta Mandarini, Eva Tollapi, Marta Zanchi, Lorenzo Depau, Alessandro Pini, Jlenia Brunetti, Luisa Bracci, Chiara Falciani
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
heparan-sulfate proteoglycans
endocytosis
breast cancer
vesicular traffic
tumor-targeting peptide
Online Access:https://www.mdpi.com/1422-0067/21/21/8282

Internet

https://www.mdpi.com/1422-0067/21/21/8282

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