Non-Coding Variants in <i>BRCA1</i> and <i>BRCA2</i> Genes: Potential Impact on Breast and Ovarian Cancer Predisposition

Non-Coding Variants in <i>BRCA1</i> and <i>BRCA2</i> Genes: Potential Impact on Breast and Ovarian Cancer Predisposition

<i>BRCA1</i> and <i>BRCA2</i> are major breast cancer susceptibility genes whose pathogenic variants are associated with a significant increase in the risk of breast and ovarian cancers. Current genetic screening is generally limited to <i>BRCA1</i>/<i>2<...

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Bibliographic Details
Main Authors: Elizabeth Santana dos Santos, François Lallemand, Leslie Burke, Dominique Stoppa-Lyonnet, Melissa Brown, Sandrine M. Caputo, Etienne Rouleau
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Cancers
Subjects:
<i>BRCA1</i>
<i>BRCA2</i>
non-coding variants
promoter
hereditary breast cancer
hereditary ovarian cancer
Online Access:https://www.mdpi.com/2072-6694/10/11/453

Internet

https://www.mdpi.com/2072-6694/10/11/453

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