The Chemically-Modified Tetracycline COL-3 and Its Parent Compound Doxycycline Prevent Microglial Inflammatory Responses by Reducing Glucose-Mediated Oxidative Stress

The Chemically-Modified Tetracycline COL-3 and Its Parent Compound Doxycycline Prevent Microglial Inflammatory Responses by Reducing Glucose-Mediated Oxidative Stress

We used mouse microglial cells in culture activated by lipopolysaccharide (LPS) or α-synuclein amyloid aggregates (αSa) to study the anti-inflammatory effects of COL-3, a tetracycline derivative without antimicrobial activity. Under LPS or αSa stimulation, COL-3 (10, 20 µM) efficiently repressed the...

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Bibliographic Details
Main Authors: Nilson Carlos Ferreira Junior, Maurício dos Santos Pereira, Nour Francis, Paola Ramirez, Paula Martorell, Florencia González-Lizarraga, Bruno Figadère, Rosana Chehin, Elaine Del Bel, Rita Raisman-Vozari, Patrick Pierre Michel
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
COL-3
glucose metabolism
microglia
NADPH oxidase
neuroinflammation
oxidative stress
Online Access:https://www.mdpi.com/2073-4409/10/8/2163

Internet

https://www.mdpi.com/2073-4409/10/8/2163

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