Sex Differences and the Role of Estradiol in Mesolimbic Reward Circuits and Vulnerability to Cocaine and Opiate Addiction

Although both men and women become addicted to drugs of abuse, women transition to addiction faster, experience greater difficulties remaining abstinent, and relapse more often than men. In both humans and rodents, hormonal cycles are associated with females’ faster progression to addiction. Higher...

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Bibliographic Details
Main Authors: Saurabh S. Kokane, Linda I. Perrotti
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fnbeh.2020.00074/full