High-Fat Diet Aggravates Cerebral Infarct, Hemorrhagic Transformation and Neuroinflammation in a Mouse Stroke Model

High-Fat Diet Aggravates Cerebral Infarct, Hemorrhagic Transformation and Neuroinflammation in a Mouse Stroke Model

Background: Stroke in context of type 2 diabetes (T2D) is associated with a poorer outcome than in non-diabetic conditions. We aimed at creating a new reproducible mouse model of stroke in impaired glucose tolerance conditions induced by high-fat diet. Methods: Adult C57BL6 mice were fed for 2 month...

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Bibliographic Details
Main Authors: Coline Grisotto, Janice Taïlé, Cynthia Planesse, Nicolas Diotel, Marie-Paule Gonthier, Olivier Meilhac, David Couret
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
ischemic stroke
hemorrhagic transformation
neuroinflammation
diet-induced chronic hyperglycemia
impaired glucose tolerance
metabolic disorder
Online Access:https://www.mdpi.com/1422-0067/22/9/4571

Internet

https://www.mdpi.com/1422-0067/22/9/4571

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